Myeloma is a potentially debilitating and life-limiting haematological cancer and maintaining quality of life (QOL) for people with this disease is important. As survival rates improve, measuring QOL will become more important in myeloma care. This article reports on a project and audit that involved measuring the QOL of patients with myeloma in an outpatient clinic in a single centre in Cardiff. The project and audit raised three main issues: measuring QOL is difficult due to its individualised nature; the tools available to measure QOL in myeloma are designed for use in clinical trials and are not easily transferable to a clinical setting; and the act of measuring QOL is just as important for patients and healthcare professionals as the results. The project has resulted in the development of a dedicated, nurse-led QOL clinic, which will be audited in future.