Proton pump inhibitors should not be used for longer than necessary, study finds
Research compares death rates of people taking PPIs with those taking H2 blockers
Proton pump inhibitors (PPIs) are a group of drugs whose main action is a pronounced and long-lasting reduction of stomach acid production. They are prescribed for prevention and treatment of acid-related conditions, such as heartburn and stomach ulcers. PPIs are widely used either as prescription or over-the-counter drugs.
Several previous studies have suggested that taking PPIs is associated with serious adverse events, including cardiovascular disease (CVD), acute kidney injury, chronic kidney disease (CKD), dementia, pneumonia, gastric cancer, Clostridium difficile infections and osteoporotic fractures.
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