<p>National Institute for Health and Clinical Excellence (2004) guidance for improving supportive and palliative care for adults with cancer identified a need for specialist teams to provide face-to-face patient assessment seven days a week. In response, seven-day working for clinical nurse specialists (CNSs) in palliative care has been introduced across Wales. In this article, a group of CNSs working in a hospital support palliative care team based in a cancer centre discuss the challenges of implementing seven-day working and an initial evaluation of its effectiveness.</p>