Depression is a common and disabling illness that can affect the physical and emotional well-being of children and adolescents. Pharmacological therapies often incur unwanted side effects, including increased risk of suicide. Literature searches for non-pharmacological interventions for depression were conducted. Ten papers were examined for themes using Critical Appraisal Skills Programme (CASP) tools. The Promoting Action on Research Implementation in Health Services (PARiHS) framework was then used to develop recommendations for practice change. Nursing staff should develop leadership, skills and knowledge in the development of nurse-led, person-centred lifestyle and dietary interventions, including the socialisation benefits of mealtimes. Further research into nursing interventions for depressive disorders in children and young people is required.