<p>Aim To describe practical experiences before, during and after gaining entry into research fields in Kenya and Uganda.</p> <p>Background Planning, conducting and implementing international research can be an arduous task. Novice researchers need practical guides to accessing international fields and mitigating challenges met in the field.</p> <p>Data sources The researchers conducted three different studies in two developing nations.</p> <p>Review methods This paper reviews challenges encountered when conducting international research. Solutions used to overcome these challenges are discussed.</p> <p>Discussion Establishing and maintaining effective partnerships is critical to the success of international research efforts. Researchers must be tactful, flexible and creative when handling methodological, ethical and logistical challenges encountered in settings poor in resources.</p> <p>Conclusion International research provides opportunities for increasing dedication, building cross-cultural competence and advancing health professional practice globally.</p> <p>Implications for research/practice This paper contributes to nursing scholarship by highlighting the practical challenges of conducting international research. Illustrations aimed at lending insight and encouraging others to expand their dedication to conducting international research are offered.</p>