The theme of World AIDS Day 2017 is ‘let’s end it’. After almost 40 years since the first occurrences of human immunodeficiency virus (HIV), it is possible to envision an end to the HIV epidemic, one of the most serious health and development challenges humanity has faced. This article provides an overview of the current approaches to the treatment, care and support of people living with HIV and acquired immune deficiency syndrome (AIDS). It also discusses the challenges associated with HIV and AIDS that remain, HIV prevention strategies, and the nurse’s role in caring for people living with HIV. It outlines the Australian partnership approach to HIV, which provides a background for reflection on the response to HIV and AIDS in the UK and worldwide.